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Podcast Episodes

The Juicebox Podcast is from the writer of the popular diabetes parenting blog Arden's Day and the award winning parenting memoir, 'Life Is Short, Laundry Is Eternal: Confessions of a Stay-At-Home Dad'. Hosted by Scott Benner, the show features intimate conversations of living and parenting with type I diabetes.

Filtering by Category: Defining Diabetes

#648 Defining Diabetes: Insulin On Board

Scott Benner

Scott and Jenny Smith define diabetes terms

In this Defining Diabetes episode, Scott and Jenny explain Insulin On Board

You can always listen to the Juicebox Podcast here but the cool kids use: Apple Podcasts/iOS - Spotify - Amazon AlexaGoogle Play/Android - iHeart Radio -  Radio Public or their favorite podcast app.

+ Click for EPISODE TRANSCRIPT


DISCLAIMER: This text is the output of AI based transcribing from an audio recording. Although the transcription is largely accurate, in some cases it is incomplete or inaccurate due to inaudible passages or transcription errors and should not be treated as an authoritative record. Nothing that you read here constitutes advice medical or otherwise. Always consult with a healthcare professional before making changes to a healthcare plan.

Scott Benner 0:00
Hello friends and welcome to episode 648 of the Juicebox Podcast.

Today I come to you with another in the defining diabetes series. Today Jenny Smith and I are going to define insulin on board the notorious I O B. Please remember while you're listening that nothing you hear on the Juicebox Podcast should be considered advice, medical or otherwise, always consult a physician before making any changes to your health care plan or becoming bold with insulin. This show is sponsored today by the glucagon that my daughter carries G voc hypo pen. Find out more at G voc glucagon.com. Forward slash juicebox. If you're a US citizen who has type one diabetes or is the caregiver of someone with type one, please go to T one D exchange.org Ford slash juicebox. Join the T one D exchange registry fill out the survey support people with type one diabetes T one D exchange.org Ford slash juicebox.

G voc hypo penne has no visible needle, and it's the first premixed autoinjector of glucagon for very low blood sugar in adults and kids with diabetes ages two and above. Not only is G voc hypo pen simple to administer, but it's simple to learn more about all you have to do is go to G voc glucagon.com Ford slash juicebox. G voc shouldn't be used in patients with insulinoma or pheochromocytoma. Visit G voc glucagon.com/risk.

Jennifer Smith, CDE 2:04
Insulin on board is an interesting topic it is

Scott Benner 2:08
and I think it's going to become more interesting as more people use algorithms to Yeah, because you're going to start thinking about it a little differently. But insulin on board is a measurement. I'm making air quotes about how much insulin is in your body that is yet to have done its job is how I think people think of it. Do you think of it? How do you think of it?

Jennifer Smith, CDE 2:34
True. And I think in in another way to define it. It's kind of like the expected it's the expected decay or action time over a defined period. So you know you've got this many units of insulin, your insulin action time is defined as four hours let's say you had four units taken 50% should be done by two hours after you Bolus if you have a four hour action window of that insulin right. But that's like the nutshell. Right? of insulin on board. I think insulin on board individually is very ill defined. It is not individualized unless you really test it out.

Scott Benner 3:29
And I so Kenny comes on and I and I think you know Kenny actually can yes on and talks about loop a lot. And if I'm not mistaken, his child's insulin action time he has set pretty short a prior to any kind of algorithm. I had Arden's insulin action time set at like two hours, two hours, I never remember, I never didn't want the pump to suggest insulin. Right. So I so I wanted that, you know, the way I talked about it with people is that there's a setting inside of your pump. And you just get to say, how long your insulin lasts for right, your insulin action time is one hour, two hours, three hours, four hours, five hours. If you use loop has an algorithm, it measures it as six, right?

Jennifer Smith, CDE 4:17
A five to six hours. If you use one particular like action, you know, profile, you can choose from multiple there's a child base, there's a adult based, then there's one that you can adjust the hours within, for the people who are doing some of their own coding and whatnot. They can also self adjust within their code, what they have their insulin action time kind of set for. But yes, each pump, whether it's algorithm driven or just conventional pump, loop pump or not. It is something that each pump has built into it. And again, I don't think that it's very well defined for people even just starting a base Conventional pump in an office clinical training, it's something that gets set, and is less than a minute in explanation as to why it's set for three hours or four hours or five hours. It's set that for three hours, and then you move on to like the next setting. Never go back to it. And they never come back to it. And I don't know how many people in a first visit, when I chat with them, we look at their active insulin time. I'm like, Well, why is your active insulin type set like this? Well, what is that? What does that mean? And where do I find that? Like, that's let's start over from insulin.

Scott Benner 5:41
Because if it because it's a it's a dummy setting, in the in a pump in a regular pump. By that I just mean, if you tell it three hours is your insulin action time, right, then it and you Bolus, I don't know 10 unit new gear at noon, two hours in the insulin on board is still going to indicate is probably being like a third of the Bolus though, correct, right? Yes. And but having said that, if you if that insulin action time was set at four hours, then it would think you had insulin on board of 4%. Right? If you said two hours, it would think it was more like 30%. And my point is, is that this, this number that gets put into your pump by a doctor who just is like I don't know, most people's is like three, and they just dial it up to three or maybe four, or maybe they're thinking I don't want you to over do it. So I'll make it five. None of that has anything to do with the impact of the food and your use of your insulin. It's it's it's a nice thing. But I think we're kind of beyond that now with technology. And you shouldn't be guessing at your insulin action time. Because it impacts insulin on board. And then what happens in real life is you eat some food. You don't do a great job of Bolus going for it for whatever reason, it's two hours after you've eaten your blood sugar's 270, you're indicating you're still going up. And then you look at the pump and go, Oh, we still has insulin on board. I don't want to do anything about this. And or

Jennifer Smith, CDE 7:09
it's recommending point two units, or like point two units. That's like a drop in the ocean. Like what point two is like nothing that's like, that's like, why would I even take it there's no purpose to just do it. And that's where people get frustrated. They're like, Darn it. That's where range Bolus came from 2.2 units, I'm going to take two units instead. And then it becomes like this willy nilly management of, well, I know the pump is wrong. Why is it wrong, though, right. And I think you made a really good sort of like comment that I think leads into insulin action was formulated to cover carbohydrate. That's how insulin rapid acting insulin was formulated to cover the expected in and out effect of carbohydrate. It's why we are very carb centric in diabetes education. Everything's about carbs. It's about counting the carbs, it's about insulin to carb ratios, right. But when we start having more than the typical well portioned, mixed meal, broccoli, grilled chicken and maybe you know, blueberries on the side, or whatever it is. Once it becomes heavier, in those other macronutrients, insulin action time, isn't wrong. But the reason that it doesn't look like your blood sugar is where it's supposed to be. Once insulin is done working, is because the other pieces of that meal weren't covered the way that they should have that. So it I mean, there's a lot of mix within evaluating insulin action time. How long does your one Bolus really stretch out and work for you? Is it getting you to where you want to get blood sugar wise? And then when you bring in pizza, versus the chicken and broccoli? What happens? Right now I'm stuck high and my pump is recommending point two units. I know I need more. We don't need more because your active insulin time is wrong. You need more because there's something else in the picture that wasn't covered. And it needs to

Scott Benner 9:30
be Yeah. So at a basic level these these measurements were set it for perfect world situations, not for the situation you find yourself in right away. There is a world where if you send your if you set your you know, your insulin action time at three hours, your insulin on board will probably reasonably be right if you're always eating the way you described. But the minute you elongate a meal impact by adding fat to it or protein or something that starts hitting You know, an hour and a half later, after you've eaten it, these are these are new impacts on your blood sugar that this, this simple, simplified formulas not thinking about. And I understand, right? Like, you can't explain all the stuff we talked about in the podcast if somebody's in a five minute doctor's visit, right? Right. And so, but the problem ends up being is you set the settings somewhere, and then you tell people, well, this is it. Insulin on board, if you have insulin on board don't Bolus, it's a, it's a generic thing to say. And you might be right sometimes, and and that might be wrong sometimes. But people get into this situation where they're in their home. And they know they should do something. And what rings in their head is the doctor told me not to correct before three hours. And I don't know if you've ever taken 24 divided by three. But there's only so many three hour segments in the day. And that's how you make yourself crazy. So waiting three hours feeling the pressure of this blood sugar's high, I don't want to do the wrong thing. The doctor said I have insulin on board still, it's sort of comes down to there's another epic defining diabetes episode that I think is called. I don't know if it crushed it and catch it. When I probably where I probably say something like, it's not stalking if you need it. You know? Yes, yes, you could stack insulin, do it wrong, make yourself very low. But it's not stalking if you need it, meaning that one meet and

Jennifer Smith, CDE 11:30
if, if you need it, you may want to go to the variables that we hash through in like very, I think really good detail, right? Because those variables are some of the reasons for saying, I'm not stalking, I'm taking extra insulin now. Because this variable is in the picture. And I know that I need it. My pump isn't recommending, but my pump doesn't have my brain. It's it's like a locked, I see this, you only need this. You are in real world. You know, you know what's going on.

Scott Benner 12:06
You need to understand I play there. Sometimes I think I say the same thing a lot. But you need to understand that 10 carbs of rice is going to impact you differently than 10 carbs of grapes than 10 carbs of pizza. And the Bolus that probably works well for the grapes, let's say doesn't work for the rice definitely doesn't work for the pizza. And so you take the insulin you think you're supposed to have you get high, take it again, a doctor would call that stalking. But I would say that if we're talking about the pizza, you just didn't understand how to Bolus for the pizza to begin with. Right? Right, or you used more insulin, or you would have timed it differently. This is the point where I've never really said this before in a defining episode. But if you tuned in to hear about insulin on board, and you're like they talked about insulin action time a lot. I think that if you really want to understand insulin on board, you should just go find the other pro tips and the other defining episodes and educate yourself about the big picture. And then I don't think you think about insulin on board anymore.

Jennifer Smith, CDE 13:11
Well, and I think the other thing, as you mentioned earlier is we become we've become in the past, I would say even three to five years of a lot of these algorithm driven pumps that people are using, I think with learning more about why is the system doing what it's doing. Why does it seem to work better than my conventional pump did? And some people get locked into the well, my system isn't giving me more insulin. I think it needs to be, but it's not giving me more. It's not helping me more? Well, our, our algorithm driven pumps have much more, I guess, a lot longer insulin on board or insulin action times, right. They're much extended comparative to what you may have had set in your conventional pump. I noticed that difference very early, going from conventional pumping to loop I did. And it was also a question for me. I was like, Well, I see it's giving me more and on my conventional pump, I probably would have given myself more with a I've got this much like hindsight that I know I need this much more, and I feel safe doing it and I can do it. But my pump wouldn't have recommended it. These systems are following blood sugar in a way that a conventional pump wasn't. And it's taking into consideration the glucose shift, where again, a conventional pump is not it's locked into one point of data that you're giving it to get back a suggestion. Whereas the algorithm driven pumps they're adjusting based on our rate of change, and the more information you feed it, the better can decide what to give you? And how long to look for that along with gets drawn out active insulin time.

Scott Benner 15:06
Yeah, it's important to know that what if you're experiencing, you know, a rise that you that you don't expect, it's not always just change your meal ratio, because your meal ratio might work really well, for a lot of things, it just doesn't work well for Chinese food, right. So you don't want to change your ratios in the pump, you want to change the way you think about that specific food. And I mean, that's a, that's a trial and error situation. But you you have to be able to look and go, my ratios work most of the time, they don't work for these foods, I have to figure out how to Bolus for these foods better. And and the other thing that what you just said made me want to talk about was, I guess I do actually still pay attention to insulin on board. But it's more about during a fall. So if I'm managing a high blood sugar down, or I have a real steady, lower blood sugar, and I want to know if it's going to drop, that's where active insulin makes is important more concerning to me than it is while I'm bolusing for food, crackers, one bolusing for food, I can see what's happening, I can see the big jump, I can see. Well, I mean, listen, I'm not into bolusing perfectly every time I don't think you should be that way. But if your blood sugar's one at a half an hour, after you ate, you didn't Bolus right. You know, like there was a way to do that better. There, that's easy to deal with. But when you find yourself at 180, or 200, and you start attacking it, and now you're dropping down. Now it's important for me to know how much active insulin is here because I can look at the act of insulin and decide how much juice as an example, would, would right counteract that act of insulin. So almost thinking of it as correcting a high blood sugar was almost like Pre-Bolus thing for the juice. And now put the juice in so they can do their job. And then the rest of it is just putting it in in a place where you kind of come in for a smooth. Yes, yeah. So you don't do it too soon or too late. And it is a lot like trying to land a plane apparently. So. Correct. You don't want to you don't want to fly off into the horizon and you don't want to crash into the ground. So good comparison. Yes. Great. I've never flown a plane in my life. And I never I flown a plane. Have you

Jennifer Smith, CDE 17:20
really? I have. Yeah, like a little, you know, like, a four seater. It's not like it was a huge plane or anything, obviously. But it was fun.

Scott Benner 17:29
Or and Lieberman was on here once and he offered to take me out. His parents live near me. And he was living in he was the CNN CORRESPONDENT Israel when I spoke to him, but I think he's back in the States now. And I was like, No, I'm not getting a small. He's like, we could fly down to here and get a sandwich. And I'm like, No, I don't know.

Jennifer Smith, CDE 17:50
It's it was it's really noisy. I mean, really, really noisy. But it was super fun.

Scott Benner 17:57
All right, so yeah, maybe I would do it. Six parachutes strapped in my face. Thank you very much for talking about it. Yes. On board with me, of course.

A huge thank you to one of today's sponsors, G voc. Glucagon. Find out more about Chivo Kibo pen at G Vogue glucagon.com forward slash juicebox. you spell that GVOKEGLUC AG o n.com. Forward slash juice box. If you'd like to hire Jenny Smith, she works at integrated diabetes.com. And she does this for a living, you should check her out. And don't forget that T one D exchange.org. Forward slash juice box link, go fill out that survey, please.

I want to thank you very much for listening. I want to thank you for sharing the show with other people. I want to thank you for the wonderful reviews and ratings that you leave. I would like to invite you to come check out the Juicebox Podcast Facebook page. It's called Juicebox Podcast type one diabetes, it's completely it's a private group is the words I was looking for. So about 23,000 people in there now they all have diabetes, great conversations going on. You can jump into one of them or just sit back and watch. I'd also like to remind you that today's defining diabetes episode was the latest in a long line of defining diabetes episodes. You can find them at juicebox podcast.com diabetes protip.com, or right there in your podcast player just search for defining diabetes juicebox they'll pop right up in your podcast player. There are so many I can't list them for you right now. And if you like the series, let me tell you about The rest of them. You know what I'm going to come back to this one diabetes pro tips, they begin at episode 210 and cover a bevy of topics. Those are also with Jenny Smith. There's the diabetes variable series also with Jenny variables that impact your type one care Quickstart episodes, how we eat everything from vegan carnivore, low carb flexitarian, intermittent fasting episodes for how we eat popular request episodes, stuff like what's in your go bag, switching to an insulin pump, how to split long acting insulin, bolusing, insulin for fat, all kinds of stuff there. What else we got? There's a great mental wellness series all about type one everything from sneaking food to hard questions to kids ask about type one. In a number of those episodes, I'll be joined by Erica Forsythe. She is a therapist who also has type one, there's a ton of Scott and Jenny episodes, so many to choose from their how to Bolus for fat and protein. We have a number of episodes about that. I have a great four part series about pregnancy with type one diabetes, and a ton more about pregnancy. Some in the defining diabetes episode, some in the pro tip episodes. Just so many we've done so many great conversations with pregnant type ones. And mothers who recount their pregnancies, ton of great stuff. I said ton a lot. I appreciate that. You're letting me go on that. But about algorithm pumping. Like if you're using a loop or any other algorithm actually don't miss the fox and the loop House series or any of the others. We just finished up the defining thyroid series which is really well received by people. And after dark so many afterdark episodes living with bipolar psychedelics, heroin addiction, we sex, divorce, sex workers, disordered eating from male and female perspectives. They're all there in the afterdark series. And last but not least, I told you I wasn't going to list the defining diabetes episodes but you know what Dammit, I'm going to you're ready. I'm gonna hammer through this. So today we did insulin on board. But going all the way back to Episode 236 When the series began, we have defined Bolus Basal honeymoon a one see time and range standard deviation extended Bolus algorithm, noncompliant glycemic index and load Pre-Bolus Trust will happen low before high brittle diabetes stop the arrows, ketones insulin resistance and over Bolus feeding insulin bumping nudge rage Bolus compression low and interstitial fluid, fat and protein rise. Dawn phenomenon smudgy effect feed on the floor insulin sensitivity factor adrenaline highs, insulin deficit growth hormone stacking insulin hydration, a lot of diabetes, moody diabetes, crush it and catch it see peptide and beta cell and of course today's insulin on board and there will be more. You can't use the tools if you don't understand what the tools are. Again, if you want to see those lists, join the Facebook page Juicebox Podcast type one diabetes, go right up to the top of the page where it says featured. And there is a post in there with lists of all of these episodes. And honestly, these are just a fraction of the episodes that are available in the Juicebox Podcast. So if you're not already subscribed, please do subscribe in the audio player that you prefer. Thank you so much for listening. I'll be back very soon with another episode of The Juicebox Podcast.


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#466 Defining Diabetes: C-Peptide and Beta Cell

Scott Benner

Scott and Jenny Smith define diabetes terms

In this Defining Diabetes episode, Scott and Jenny explain C-Peptide and Beta Cell

You can always listen to the Juicebox Podcast here but the cool kids use: Apple Podcasts/iOS - Spotify - Amazon AlexaGoogle Play/Android - iHeart Radio -  Radio Public or their favorite podcast app.

+ Click for EPISODE TRANSCRIPT


DISCLAIMER: This text is the output of AI based transcribing from an audio recording. Although the transcription is largely accurate, in some cases it is incomplete or inaccurate due to inaudible passages or transcription errors and should not be treated as an authoritative record. Nothing that you read here constitutes advice medical or otherwise. Always consult with a healthcare professional before making changes to a healthcare plan.

Scott Benner 0:00
Friends, you're listening to Episode 466 of the Juicebox Podcast.

Today, you're going to get a two for one defining diabetes. As Jenny Smith and I define beta cells, and C peptide. There's actually some bonus BONUS stuff in this too. For one, it's almost four for one, but I don't want to get confusing so you'll see as it goes. While you're listening, please remember that nothing you hear on the Juicebox Podcast should be considered advice, medical, or otherwise, please always consult a physician before making any changes to your health care plan. We're becoming bold with insulin. After you're done listening to the podcast, they head to Omni pod.com Ford slash juice box and take the pod for a test drive. You can ditch your daily injections, or send your pump packing, try the Omni pod tubeless wireless continuous insulin management system. All you have to do is head on the pod comm forward slash juice box and when you get there, you're going to find out if you're eligible for a free 30 day trial of the Omni pod dash. That is crazy. Just get over I mean for free for a whole month. I know you know this, but there are 12 months in a year, you're getting 1/12 of the Year for free. You may be thinking right now Scott is on the pod still offering the free no obligation demo pod at on the pod comm forward slash juicebox? Well, yes they are. So head on over and see what option is right for you. There are also links in the show notes of your podcast player and at Juicebox Podcast comm if you can't remember on the pod comm forward slash juice box. I feel like I say this a lot of these in the beginning of these defining episodes. But I'm just going to come clean and tell you that I hear people say C peptide all the time. And I don't know what it means by the end. But here's my best story. A person who I saw online once who's been alive for just you know, must be 80 years old, said Type One Diabetes their whole life talked about one time how he missed older insulin because of C peptide. And I never understood what he was saying. And I'm wondering if like, was there There used to be an additive and insulin that doesn't exist anymore? Am I confusing two phrases Jenny's face is telling me I'm completely wrong about this?

Jennifer Smith, CDE 2:45
No, it's a really well and this statement in and of itself, you're not necessarily wrong. But

Unknown Speaker 2:52
did they use the Add

Jennifer Smith, CDE 2:54
older insulin, they wouldn't have added c peptide, there's no purpose. So I think the definition of C peptide will give you reason for like the faces that clearly nobody else can see that I'm making to you look absurd.

Scott Benner 3:10
It kind of goes to my confusion about it because no one says these this word out loud ever like I am as involved in people talking about type one diabetes as any person could be. And no one says c peptide. But I think it's important to understand. So that's why I'm going to pick your brain for it. So what is it?

Jennifer Smith, CDE 3:31
So it's easy, it's actually it's a byproduct, essentially of insulin production. So when you're paying kurious, not outside insulin light from your bottle or your vial that you pump in or in Juju inject in pancreatic insulin that is created has a has c peptides, which are really just amino acids. It's like a structure right. And when the insulin is made, think of it as a round ball, for lack of a better visual. And when insulin gets released into the bloodstream, a part of it gets cleaved off from the creation and that part, which looks like a C way it looks better for you. So it's called C peptide c peptide, to my understanding really has no has no purpose offs of the creation of the insulin. Once insulin gets into the bloodstream and is doing its job. C peptide is what's left over sort of like byproduct. And so it floats around and it's a marker of how much insulin is being produced by the beta cells in the body. But outside generically created insulin or lab created insulin does not have C peptide in it, it was not created by the body. So that's why somebody with diabetes even using rapid insulin or Basal insulin or anything, they can still have C peptide levels drawn to see what is their actual beta cell pulled out, if any? Because the injected insulin doesn't have it, so it doesn't make a difference. But does that?

Scott Benner 5:16
No, it does, but it doesn't. So it doesn't do anything. There's no, like C peptide has no function, it's just a measurement we use to say. Okay, so the, the less, I'm assuming the less c peptide that can be found with testing is an indication of less and less insulin being produced by the pancreas.

Jennifer Smith, CDE 5:37
So there, there are markers, you know, certain lab levels that if it's under this level, that's diagnostic diagnostic of type one diabetes, some people get their c peptide levels tested through the course of the years, you know, to see is it declining? Is my C peptide level? Obviously, still type one, but is it kind of like stabilized? Am I not really losing any more betas or whatever? I mean, quite honestly, obviously, we know that once you have type one diabetes, you have type one diabetes, you know, but I think another way to like think about C peptide in terms of like it being a byproduct, it's sort of like when you're burning like wood in your fireplace. C peptide is like the smoke, that just sort of like it doesn't really have a purpose. It's not going to give you heat, it smells nice, maybe. But it's

Scott Benner 6:30
a good measure that there's a fire somewhere,

Jennifer Smith, CDE 6:32
but it's a good measure that there's a fire somewhere. Exactly. So it's just a it's a marker, essentially. So that's it. That's why I kind of made that funny face at the comment. Because older insulin and I'd have to do some homework, but older insulin to my knowledge didn't really I mean, it wouldn't have had c peptide for a benefit of the insolent action.

Scott Benner 6:53
It makes me wonder if I hate to say this, like this, but it makes me wonder how sometimes people see things that aren't really there. Like maybe this person saw their c peptide, like falling more after they switch to more modern insulins and made the correlation or I mean, could could the older insulins have protected beta cells? No, right? There's no there's no I mean,

Jennifer Smith, CDE 7:23
really, the only protection from beta cells in the initial diagnostic time period is, the faster you get containment of your blood sugar, the less stress on those betas, as well as the knockdown of the immune system that is constantly trying to destroy them. So you, you add in sort of this outside insulin to keep the blood sugar's controlled, which means the betas don't have to work as hard. So you may in terms of that help preservation of the beta cells initially. So the better control from the beginning, the more betas you're likely to retain. Okay, well, in a general sense,

Scott Benner 8:03
let's combine this, let's just keep going for a second. I know this probably seems overly simplistic, but maybe it isn't.

Alright, so we've already talked about the Omni pod. And you can go check out that free 30 day trial of the dash system at Omni pod comm forward slash juicebox, as well as demo pods and just go see if you're eligible. But we still haven't spoken about the Dexcom g six today@dexcom.com forward slash juice box, you can learn more about the Dexcom g six Siri integration. It's indicated for children two and above that you can share your data with up to 10 followers. And that there are smart device compatibility with tons of phones that are both Android and iPhone. There are customizable alerts and alarms that will let you know if you're heading higher or lower, and leaving the range that you get to set. There's so much going on with the Dexcom g six, it gives back. You know what I was gonna say gives back data that helps us make great decisions, but it just gives back if you use man made insulin, the Dexcom g six is a friend. Check it out@dexcom.com forward slash juicebox. There you can get started with the Dexcom g six to tiny bit of information that you fill out and you're on your way. The Dexcom g six is one of the best decisions we've ever made for my daughter, my daughter and I use the Dexcom g six every day, every three days not even enough. We just use it constantly. It's there, but it needs to be there. It's not in the way when it doesn't. Check it out. Last thing before Jenny and I define beta cells and some other stuff. Don't forget to go touched by type one.org and follow them on Facebook and Instagram touched by type one.org. Just go check them out, you'll be happy that you did.

A beta cell is a type of cell found in the pancreatic isolettes that synthesize and secrete insulin and Amylin. beta cells make up 50 to 70% of the cells in human isolettes. in patients with type one diabetes, beta cell, mass and function are diminished, leading to insufficient insulin secretions and hyperglycemia. I guess we need to tell people what beta cells are just because they came up and I've never said it out loud on this podcast once I don't think so. I'm gonna do my best and then you're gonna tell me everywhere I'm wrong. But again, going back to an episode I did recently, I found out that beta cells are like, the only have like a gram of them in your body. It's apparently it's

Jennifer Smith, CDE 11:05
tiny.

Scott Benner 11:07
Yeah, yeah. So okay, let's figure that out. The pancreas

Jennifer Smith, CDE 11:09
is a very tiny, it's really actually it's a gland. So the your, your pancreas is tiny, comparative to the very large organs like your liver and your stomach and your heart and everything. I mean, the pancreas is this tiny little brain.

Scott Benner 11:27
That when that was said, again, I think in Episode 451, I was like, Ha, really, like, you know, like, I do love doing this podcast, because people say things. I'm like, I never do that. But, uh, but so there are these, these beta cells, and their job right? make insulin, and Amylin, which I guess we have to say now, but Amazon is because we keep bringing things. But So in a nutshell, what do they do?

Jennifer Smith, CDE 11:54
So the I mean, the the definition of a beta cell really is just, it's any of the cells in the islets.

Scott Benner 12:03
islets of langerhans is really, that it's insulin producing cells as a beta cell. That's essentially what it does. It makes insulin and Amylin or Jesus, I split amyloid poly peptide is a 37 residue peptide hormone, it is co secreted with insulin from the pancreatic beet beta cells in the ratio of approximately 100 to one. So does that are we not getting Amylin, either? If you have Type One Diabetes called

Unknown Speaker 12:36
sembalun on the market, you know, both sembalun

Unknown Speaker 12:39
I have heard about someone? Yes, yeah,

Jennifer Smith, CDE 12:42
it's an injectable form of amlan. It's so in the simplest term, yes. If you have type one, and you have beta cell issue, obviously, you're not producing insulin, well, if you have beta cell destruction, because Amylin is also produced there. You also have a lack of amlan. An amlan is, like I said, there is an injectable form of it now on the market is going on the market for a long time, actually called sembalun. And it's essentially, I mean, it's a, it's a piece that helps in the way that insulin is used after secreted in terms, mostly around meal time management. So, people who use similasan as a addition to their diabetes management, they take similar, it's an injectable doesn't come as a pill. So it's an injectable that you take along with meals. What it does is it helps to slow some of the fast digestive nature of that spike in the aftermath of a meal. It also helps to for many helps to reduce a bit the amount of actual insulin that you need to cover the meal. So you get a slower glycemic

Scott Benner 14:10
response from a meal, helping to prevent spiking. It also for many, like I said, helps to bring down the amount of insulin to actually cover the meal. The ADA says Amylin is a peptide hormone that is co secreted with insulin from the pancreatic pieces, beta cells and is thusly and and is thus deficient in diabetic people. It inhibits glucagon secretion, delays, gastric emptying, and acts as a satiating agent, so helps you feel full.

Unknown Speaker 14:44
Yes,

Jennifer Smith, CDE 14:44
I actually have somebody I work with. I've not worked with her for about two years or so. But she actually used the tiniest dose of similar or Amlin in the afternoon, because that was her time that she just she couldn't get over her. appetite. He just was so hungry in the afternoon despite eating really good lunch starting with a breakfast, you know, all the tricks that we aim to do, you know, for like decreasing the amount that you might eat. But similan did the trick. He didn't actually, I mean, she kind of used it in an off label sense. She just took the tiniest amount in the afternoon, sort of around like two o'clock ish, her snacking kind of came into play by about four. And so just that tiny amount of the amblin in her system helped to decrease her desire for food into the afternoon.

Scott Benner 15:35
Okay. sembalun is an injectable medicine for adults with type two and type one diabetes to control blood sugar, similar and slows down the movement of food through your stomach affects how fast sugars enter your blood system after eating is always used with insulin to help lower blood sugar during the three hours. Which which by the way, I made a joke with someone the other day, I said, I'm very good at managing blood sugars, and I can't pronounce post Pratt. No. I said that's my, that's my genius. I don't know how to say that. And, and I still understand what it means. I'm wondering as I'm sitting here, how many weight weight loss doctors use similan off label?

Jennifer Smith, CDE 16:21
I wouldn't. Yeah, that would be a good question. I don't know. I don't even know if it would be without a diagnosis without a diagnosis of diabetes had really question because there are a lot of other. There are a lot of other meds that are specific more for weight management. Well, I

Scott Benner 16:40
found my answer already. It says that using it off label without diabetes, could endanger patients due to a higher risk of hypoglycemia. Okay, can make you Well, yeah.

Jennifer Smith, CDE 16:50
Because it really does suppress glucagon excretion. Right? And so if you have a decrease of that you also have less chance of your body responding to lows. Yeah, true like it's supposed to.

Scott Benner 17:03
So it doesn't have it doesn't have any use outside of people who have diabetes. Interesting. From what I've heard. Yeah, that's interesting. All right. We did it right. Hey, we said but beta cells all we said was c peptide ever somehow got into Amylin, which took us the similan and now we're done.

Unknown Speaker 17:21
Yay.

Scott Benner 17:27
I'd like to thank Omni pod Dexcom and touched by type one for sponsoring this episode of the Juicebox Podcast. Learn more about touched by type one at touched by type one.org or follow them on Facebook, and Instagram. Don't forget to see if you're eligible for the free 30 day trial the Omni pod dash at Omni pod.com forward slash juice box. And of course check into that Dexcom g six continuous glucose monitor@dexcom.com forward slash juicebox. There are links in the show notes of your podcast player and at Juicebox Podcast comm all of the sponsors and there's even a way for you to contact Jenny in there.


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#463 Defining Diabetes: Crush It and Catch It

Scott Benner

Scott and Jenny Smith define diabetes terms

In this Defining Diabetes episode, Scott and Jenny explain Crush It and Catch It.

You can always listen to the Juicebox Podcast here but the cool kids use: Apple Podcasts/iOS - Spotify - Amazon AlexaGoogle Play/Android - iHeart Radio -  Radio Public or their favorite podcast app.

+ Click for EPISODE TRANSCRIPT


DISCLAIMER: This text is the output of AI based transcribing from an audio recording. Although the transcription is largely accurate, in some cases it is incomplete or inaccurate due to inaudible passages or transcription errors and should not be treated as an authoritative record. Nothing that you read here constitutes advice medical or otherwise. Always consult with a healthcare professional before making changes to a healthcare plan.

Scott Benner 0:00
Hello friends and welcome to Episode 463 of the Juicebox Podcast today, Jenny and I are going to define a diabetes term that I made up.

Don't tell the other episodes, but I quite like the defining diabetes series. What was once just in my head and idea of like, oh, I'll tell people the definitions of words so they know the tools they're using and what they're supposed to do. But I've come to see these episodes is more than that as time has passed, I think they're their own special little. I don't know, I just like them. Like a Mini Pro Tip series, defining diabetes. They're just good. And they're helpful. Actually, they're made even better with the presence of Jenny Smith, my friend and certified diabetes educator who helps me on these and the pro tip episodes. Today, Jenny and I are going to define crush it and catch it. There's a little more to it, actually, there's crush it, catch it. And well, you'll find out in a second. But I just like crush it and catch it. The rest of its like implied once you understand you'll see in a second. Please remember while you're listening that nothing you hear on the Juicebox Podcast should be considered advice, medical or otherwise, please always consult a physician before making any changes to your health care plan. We're becoming bold with insulin. Hey, new listeners. Did you know bold with insulin actually comes from the title of Episode 11. I thought I would tell you that because now that the podcast is seven years old, it's possible you don't even know how this thing got started. This episode of The Juicebox Podcast is sponsored by the Contour Next One blood glucose meter. It's the meter my daughter uses. It is the most accurate meter I've ever held my hand. And it's absolutely lovely. Check it out at Contour Next one.com forward slash juice box. You know what else this show is sponsored today by the glucagon that my daughter carries g vo hypo pen, Find out more at G Vogue glucagon.com forward slash juice box I have come to I broken down the idea of how do I get a blood sugar back down into three simple words. I crush it, catch it and start over. Okay, so if I see it, if I see a blood sugar that's high, and it's stuck, instead of messing with it, I crush it, catch it and start over. Now sometimes I crush it and it catches itself. And those are days when I'm like oh, I really did it. And then there are some days when I crush it so hard, it needs to be caught with some sort of fast acting glucose. This comes up a lot when I'm talking to people because I just feel like I feel like staring at high blood sugars is a bad idea. Now when I used to say this, people say oh, it's not good to bring your blood sugar down too quickly. And I know it isn't. But is it not? A good idea when your blood sugar is high all the time to bring it down too quickly. But what about a person whose blood sugar is normally like 85 to 105 and it sits there most of the time but then you get this big spike from something you messed up or did wrong or bad pump side or whatever? Is there any value in watching it and bringing it down slowly over four hours versus crush it? Catch it

Jennifer Smith, CDE 3:40
there when I'm glad you kind of brought it up because that was like the first thing on my mind to like spit out

Scott Benner 3:46
was I know you would

Jennifer Smith, CDE 3:48
it really does depend I mean somebody who's typically sitting in a nice beautiful, you know, glucose range that they're happy with. And now oh, you know, grandma's apple pie came along and I thought I'd only one piece and now I've eaten three and Oh, I didn't Pre-Bolus that I you know all the things that go into a higher blood sugar that happens occasionally. The occasional high blood sugar that you do your little you know, crush it catch it kind of component. Is that detrimental? No, I mean, you're taking care of the high blood sugar, you're bringing it down, you're doing it quickly. I would say that the opposite of that though, you know for a high blood sugar that's that's randomly high. And you're kind of worried about doing that and bringing it down so quickly is there is there trauma, the same way on just leaving it hanging high and come down slower by just taking a small amount and gradually getting it down? I think they're both honestly about the same in terms of any potential like you know, back end, which I don't see there at all, you know problems and you either take care of it on the back end On the front end quick and it comes down. And now you don't have to do it the high blood sugar anymore, or you end up with a high blood sugar for hours watching, it's like slowly come down. And you may not feel great during that lengthy time. But on the same if you crush it early, and it drops really fast, you also might feel the drop. Yeah, too. So you know, in either of those, I don't think that it's necessarily bad. The long term of consistently doing that, like if you are the roller coaster, and you're constantly crushing highs, and on the back end catching them with a load of extra food. They're in something needs some adjustment,

Scott Benner 5:41
right? And so that phrase would not come into my mind. If Arden was constantly high, I would think oh, there's so many other things that I don't understand. I am really talking about specifically, when you just have this, like out of nowhere, like where did this come from? Because I think one of the problems with messing with it for hours is that that runs into another meal. And now you don't have any resolution of the carbs. And this the insulin right? Like there's no, like I found myself years ago always saying to my wife, look, we need to get this down, get it level, get this insulin out of her so we can start over again. Because if not, you have all these other variables going on. You don't know which ones are impacting and then you go into another meal and it takes years to be able to just on the fly, go Okay, there's still some active insulin but the food's gone now. So I'll Bolus this and I'll take away 10 cars because I know there's some insulin left like most people can't do that off the top of their head, right? So I my my theory has always been get it down as fast as you can. Because the insulin you use to get it down is kind of gone after that, like it gets. I don't know if this is a technical term, but it feels like it gets used up dealing with the carbs Does that make sense?

De veau hypo pan has no visible needle, and it's the first pre mixed autoinjector of glucagon for very low blood sugar in adults and kids with diabetes ages two and above. Not only is chivo hypo pen simple to administer, but it's simple to learn more about. All you have to do is go to G Volk glucagon.com forward slash juicebox g vo shouldn't be used in patients with insulin, Noma or pheochromocytoma. Visit g Vogue glucagon.com slash risk

are you or your child carrying around an old busted up nasty blood glucose meter? Are you not even certain if it's accurate? Does that sound like the situation you find yourself in because if it does, it would be very easy and possibly financially advantageous to check into the Contour Next One blood glucose meter. This is the meter My daughter has been carrying now for a couple of years. It is phenomenally accurate for us. I'm talking about a good old fashioned blood glucose meter that just works. It's got a bright light. So when you're using it at night, you can see what you're doing. The test strips allow for second chance testing, meaning you can hit that blood drop not quite enough and go back in and get more without messing up the accuracy of the test or wasting a strip. And it's possible that you could be eligible for a free meter. And you can just find that out right now. At Contour Next one.com forward slash juicebox. Alright, so go check out that g vo glucagon, the Contour Next One blood glucose meter. Even there's a link in that show notes there for Jenny. A lot going on there. You can find these links. Like I said in the show notes of the podcast player. We're at Juicebox Podcast comm I don't know if this is a technical term, but it feels like it gets used up dealing with the carbs. Does that make sense?

Jennifer Smith, CDE 9:12
Yeah, I usually say it gets eaten up faster. It's like there's so much sugar for it there when you've got a high blood sugar that all that insulin gets sort of used up faster. There's it's kind of like the same concept of a Pre-Bolus is you're getting the insulin action going now to hit what's coming and get it used up and on the back end. If you've done it right and you figured it you should have a smooth landing.

Scott Benner 9:40
It's always it always appears in my mind like a fistfight that just goes to the death that just like when it's over, both fighters just drop over backwards and on their way down. They're like well done and then they're they're just gone. they ever get back up again. You know, and, and you're right. That is how I talk about and how I think about Pre-Bolus Singh, which is to put Both people's aggression at the same time make the insulin working while the carbs are working. So that one's not not doing its job without the other one because how you get a higher low blood sugar. But so in a bigger idea. I hear it's exactly right, like so what do you do in that situation? Like, how does Jenny handle a high blood sugar that she gets?

Unknown Speaker 10:22
She doesn't like high blood sugar.

Jennifer Smith, CDE 10:27
I like your I like well, one, you know, with using the system that I use for managing, I don't typically deal with that unless I have a pump site that's gone bad and hasn't been dealt with obviously. And for some reason, I haven't paid attention to any alerts and alarms that are going off on my CGM. So there are lots of catching points that obviously I haven't I know a lot of people use similarly. But with high blood sugars, I do the crush it catch it kind of thing. More than not,

Unknown Speaker 11:01
I think there's because I don't

Jennifer Smith, CDE 11:02
want to sit high. I don't like sit and kind of like you with my day the way that it goes. I don't want to have to wait out a high to eat. As often my meals are with my kids. And I don't. I don't want to sit there while they're like chowing down. I'm like mommy's got to sit here.

Scott Benner 11:26
Kelly's not saying she feels that her kids will feel odd. If she's not eating. She's saying she doesn't want to watch somebody eat and not

Jennifer Smith, CDE 11:32
be eating at the same time. Right. That's the enjoyment of a meal together.

Scott Benner 11:36
I think it's a abundantly clear why you and I get along about talking about diabetes. So I was thinking now for the alternate viewpoint. Here comes Jenny with exactly what I just said. Yeah, I just think that I think it leads to so much more success. Because that staring at highs is stress inducing, and like people are like, well, I don't know, I'll make myself low. And I get that, like, if you're hearing this episode, first. Go back and listen to the pro tip series. Don't start with this. This is like ninja level, like I already understand what's going on 1000 times over. And I've got a high blood sugar. You know, if you Oh, sorry, I don't know, I was gonna say if you usually have high blood sugars all the time, your basil is wrong, you don't understand how to Pre-Bolus like, all these other things are first not this. This is not step one.

Jennifer Smith, CDE 12:28
No, no. And I was also gonna just sort of go back and say, you know, my, my day to day like crush, it is definitely much more the case overnight. I mean, my husband will wake up to an alarm. But he is definitely much more the like, sleep through a train coming through the wall than I am now have being a mom and waking up to everything. So overnight, I can say because I am, I am my own manager. I don't have anybody catching or following or anything for me. So if there was a conservative time that I'm going to do less aggressive correction for a high, it's definitely going to be overnight. And it's usually if I've had a highlight that overnight, it's usually like, the pump site is bad, or it's gotten pulled out and like I've got this dangling pod on my body and I haven't obviously gotten insulin and then it leads to well, how much insulin do I have left? So it's kind of a questionable, and I'm a lot more conservative. Sure, for my own self overnight. Because

Scott Benner 13:33
Yeah, I would think that for an adult, it's different than for a caregiver for certain and, and I don't want to give anybody the impression that I use, you know, 50% more insulin than the situation needs. And then I just give her like a filet mignon dinner at the end, like, although, I could go into how you can get out of a high and go into a meal by correcting the high end Pre-Bolus eating the meal, even sometimes hours ahead of time, and then just introducing the food at the exact right time. Maybe that does fit in here. But we're not talking about that right now. So I don't I mean, I don't want anybody to think that I'm overdoing it over time, I've learned that you know, I can be really aggressive here and maybe I'm gonna mess by eight carbs worth of insulin, right like just a little bit and you can kind of, you know, add a little bit in I there's an episode called Utah Gen, where I talk about how I how I helped the person over the phone. This is probably not something I should have recorded. But how I helped the person over the phone bring like a seven year olds budget or from 400 to 70 and like two hours, and it involved crushing it and then introducing a meal at the right time. And that kid's blood sugar went like 76 I think if I'm remembering it just leveled right out, it was like that was one of my, my most happy moments in my life. Walk around my house with my head. So I was like I did it. And then she ruined it by feeding him but that's not the point. Anyway, it's a great app. But not what I was talking about. Alright, Jenny, I'm gonna stop putting his

Jennifer Smith, CDE 15:03
reference to it, though. I mean, in terms of like that introduction of the meal at the right time, I think when you said this is like ninja level? Yeah, I agree. Because over time you have an idea, you have a sense of how much to potentially crush it with. And where, with hindsight, you can tell where you're going to need to add something because it's you're not going to, it's not going to catch it on its own, you're going to have to help with the catch.

Scott Benner 15:30
Yeah. And if somebody is listening to this and thinking, Oh, yeah, I try that all the time. I always mess it up. I really genuinely think go listen to the pro tip episodes, because then you'll get through the little reasons why you mess that up. Because, you know, I could go one of them is that people are constantly chasing blood sugars. They're always like on the wrong timeline. I don't like no one other way to put it other than to say, insulin you use now is for later, but a better way to think of it is that insulin from before is affecting you now. And if you're trying to affect before, now, you're caught in a time travel movie, and you're on the wrong end of it. So anyway, try the pro tip series. Okay, Jenny, thank you very, very much.

Jennifer Smith, CDE 16:12
Yeah, you're welcome.

Scott Benner 16:19
A huge thank you to one of today's sponsors. Gvoke glucagon. Find out more about Gvoke Hypopen at Gvokeglucagon.com/juic box. you spell that? g v o OKEGL. UC, ag o n.com. forward slash juicebox. Have you been thinking about that Contour Next One blood sugar meter. Have you been thinking about that Contour Next One blood glucose meter since I brought it up earlier, this is your time. Go check it out. ContourNextone.com/juicebox. You can find links in the show notes, too. Hold on a second, I'm gonna run out of music. You can find the links in the show notes to today's sponsors to Jenny Smith. And to all of the sponsors of the Juicebox Podcast. Right there. In your podcast player. There are show notes in your pocket, podcast podcast, there are show notes in your podcast player, you can click on them from there. And you know, the links are there. Or I don't want to get too technical when I say the links are there, or you can find those links at Juicebox podcast.com. Allow me to take this moment to thank you for listening to the Juicebox Podcast for sharing the show with other people. And for making last month march of 2021. The most popular the most downloaded month ever in the history of the podcast. I'm not giving away the numbers. But last month, did by a multiplier better than the first year of the show. Is that not crazy? Anyway, I have you to thank. So thank you. I appreciate it. Again, when you share the show when you subscribe in a podcast player, when you tell somebody about it, when you leave a review, and you're like oh my god, I love this podcast as a review. And then you give like a really thoughtful reason why those reviews are very helpful. Mostly for listening. That's the best thing you can do for the show, listen and tell someone about it. I really appreciate this. I feel like I've gone on too long about this now, but there's no going back. And I don't feel like editing it out. So I'll see you soon with another episode of the Juicebox Podcast. I'm just going to keep talking you can leave if you want to. But some people don't know about the other episodes that I think would be really helpful to them. So I'm going to take a moment. Juicebox Podcast comm is the website for the show. Everything you need is there, there's menus at the top. And you'll be able to find the diabetes pro tip episodes, and the defining diabetes episodes under one link, the link that says diabetes pro tip. If you can't remember that you can just go to diabetes pro tip comm where I've also put those episodes. I know a lot of you find the show. And people tell you Oh, if you listen to this podcast, like your variability will get better and you're able to go down you just have a better idea what you're doing. And everybody's like, Well, how do you do that? I think it's by listening to the show. I think that listening gives you a firm understanding through conversations with many people who are parents of children with Type One Diabetes, or adults who have lived with diabetes for a long time. Just hearing the conversations, hearing ideas come up, things get spoken about. I find very helpful. I find it builds your kind of diabetes knowledge. But if you really just want to dig into management ideas, you are looking for the defining diabetes episodes just like this one and The diabetes pro tip episodes. So again, diabetes pro tip comm they're also right there in your podcast player, the thing you're holding right now with your phone. The Pro Tips begin at Episode 210. They do not run concurrently. So you have to find them. And I think I say I think but I'm looking so it seems disingenuous. I was buying time the defining diabetes episodes begin at Episode 236. There are many of them actually.

Probably number in the dozens. And I don't see any end to them as we define. You know, I don't even see them as like definitions. I started talking about this the beginning like it's not just like Bolus means this. It's Jenny and I, we define it, but then we talk it through. And now you know what that tool is, it would be like, it would be like if you came from another planet, and someone handed you a hammer and a pair of pliers and a screwdriver and told you to go put together a bed. You might not know what the hammer is for. You wouldn't even know what it was called. So if you were helping me and I said Pass me the hammer you wouldn't know. So I like for you to know what a Bolus is what basil is why hydration is important. What's an insulin deficit? His feet on the floor a thing? What is the fat and protein rise a compression low or rage Bolus? Like I want you to? I want you just to instinctively know this is a hammer. I know what a hammer does. And that way when you need the hammer, you won't hesitate. To me that's what the defining diabetes series is about. And then while there is no doubt that I would love for you to listen straight through this podcast, start at first one and listen all the way through. I know not all of you are going to do that. If you did, you would glean everything that is inside of the pro tip episodes. Don't skip the pro tip episodes. Just listen to them straight through Episode 210 diabetes pro tip newly diagnosed are starting over and they go on from there. If you're not an MDI, still listen to the MDI episode. Right if you're on MDI, still listen to the Pre-Bolus episode. If you're on MDI, listen to the insulin pumping episode. If you've never had to CGM in your life still listen to the mastering a CGM episode. Don't miss bumping and nudging the variables exercise like don't just skip one because you think oh, this isn't for me. Those are going to lay down a firm foundation around your diabetes management in my opinion, and they're free so why the hell not right. Okay, thanks so much. Now I'll really see you next time. Bye bye. Hit subscribe.


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