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Scott Benner 0:00
Hello friends and welcome to episode 1240 of the Juicebox Podcast

I'm back with another News episode and other type one diabetes informative little what's going on in the world 15 minute podcast episode just for you while you're listening to it, please remember that nothing you hear on the Juicebox Podcast should be considered advice, medical or otherwise Always consult a physician before making any changes to your health care plan. In just a moment, Scotty is going to read you the news. When you place your first order for ag one with my link, you'll get five free travel packs and a free year supply of vitamin D. Drink ag one.com/juice box Hey guys, T one D exchange.org/juice box head over there. Now take the survey we're looking for type ones and the caregivers of type ones who are US residents to spend 10 minutes completing the survey to help type one diabetes research T one D exchange.org/juicebox. If you're looking for community around type one diabetes, check out the Juicebox Podcast private Facebook group Juicebox Podcast type one diabetes. I'm introducing a new advertiser today, hold on one second to learn more.

Your kids mean everything to you, and you do anything for them, especially if they're at risk. So when it comes to type one diabetes, screen it like you mean it because if even just one person in your family has type one, your child is up to 15 times more likely to get it. But just one blood test can help you spot it early. So don't wait. Talk to your doctor about screening. Tap now or visit screened for type one.com To get more info. This episode of The Juicebox Podcast is sponsored by screen it like you mean it.com Everybody seemed to enjoy when I read the news last week and a short episode. So I'm going to do it again this week with a twist. This week I'm going to tell you a little bit about stuff. I've heard a little bit about stuff I've read and we're going to let chat GPT tell us a little bit. Let's start with the old chatter GPT or I asked it for a brief synopsis of some of the latest type one diabetes news and it broke it down into five different areas. First area was vertex pharmaceuticals. Stem cell therapy, says that positive results had been reported from a trial where participants with type one diabetes were able to produce their own insulin following treatment derived from stem cells. And then I said to chat GPT break that down for me with some easy bullet points and it did positive trial results. Vertex pharmaceuticals reported successful outcomes from a stem cell trial for type one, participants in the trial were able to produce significant participants in the trial were able to produce sufficient insulin on their own after receiving the stem cell therapy says that the therapy mechanism is that the treatment involves using stem cells to regenerate insulin producing cells in the pancreas. This therapy offers significant hope for more effective and long term treatments for type one impact on patients. It says the ability to produce insulin independently blah, blah, blah research significance. Yeah, but was this a human trial? Or mice? Let's see if it knows it's looking on the interweb boopity boopity boopity Boop it's looking at clinical trials sense.com. Let's see here the key points recent advancements, I guess of action, safety and tolerability, clinical trial details global expansion. The stem cell therapy VX 880 is currently undergoing a phase one slash to clinical in trial on human so that's cool. Participants in the trial have shown significant improvement with some achieving insulin independence. For example, one patient achieved insulin independence at day 270 With an HPA once they have 5.2 v x eight ad involves the infusion of stem cell derived fully differentiated isolated cells into the hepatic paddock excuse me, portal vein. These cells are designed to restore pancreatic isolate cell function enable glucose responsive insulin production is very cool. You got to ask yourself though, couldn't your autoimmune issue just go get those cells too but sure we're getting to that. They say the therapy has been well tolerated with most adverse events being mild to moderate no serious adverse events related to the treatment have been reported. Clinical Trial details. The trial is multi centered, single arm and open label designed to evaluate the safety and efficacy of VX 880. It includes multiple parts with approximately 17 patients expected to be in one rolled. All right. That's pretty cool. Thank you chat GPT Overlord, that was lovely. Let's go to the next thing it told us about. The FDA has approved land teacher the first donor cell therapy specifically for type one diabetes patients with severe and reoccurring low blood sugar. Clinical trials showed that many participants lived without external insulin for up to five years post therapy that's led tindora has an FDA approval. Let's find out more about that, shall we? I'll say to the Overlord, tell me more about the Latendresse approval. From the very beginning, your kids mean everything to you. That means you do anything for them, especially if they're at risk. So when it comes to type one diabetes, screen it like you mean it because even if just one person in the family has it, your child is up to 15 times more likely to get it to screen it like you mean it. Because type one diabetes can develop at any age. And once you get results, you can get prepared for your child's future. So screen it like you mean it type one starts long before there are symptoms, but one blood test could help you to spot it early, before they need insulin, and could lower the risk of serious complications like diabetic ketoacidosis or DKA. Talk to your doctor about how to screen for type one diabetes, because the more you know, the more you can do. So don't wait. Tap now or visit screened for type one.com. To learn more. Again, that screen for type one.com screen it like you mean it give me some bullet points. Boop boop, boop, boop doesn't make that noise. It's actually very high tech. It's already typing here. Here's some key points about the FDA approval. The tindora is the first ever approved cell therapy for type one diabetes patients with severe and reoccurring but while we already read that, it involves the infusion of ice blood cells from deceased donors into the patient's liver, enabling the production of insulin with the body. In trials 21 of 30 participants did not need insulin for at least one year after receiving the therapy. 11 participants remained insulin dependent independent excuse me for one to five years and 10 participants. For more than five years, five participants required external insulin after the therapy and did not achieve insulin independence. There were serious adverse events including two deaths during the trial, one from multi organ failure and sepsis and another from progressive confusion and global atrophy. These events were associated with unnecessary Amin Oh, immunosuppressant therapy that goes with it. So they're given you the cells but you gotta get the your immune system suppressed. Ah, okay. This is this, this treatment is aimed at patients with a type one diabetes experiencing recurrent severe hyperglycemia and those with hypoglycemia unawareness, making it a crucial option for those who cannot maintain stable glucose levels through current methods into the liver. Okay, so All right, well, this is I mean, it's interesting stuff you don't I mean, it's just I don't think it's ready to be on your Walgreens counter just yet. How about this CRISPR therapeutics and vitae site have received Health Canada approval to begin trials for VCT x 210 and CRISPR edited stem cell therapy aiming to replace insulin production beta cells without the need for immune Oh, suppression. Hold up a second. Let's let let's let him tell me more in bullet points, because Scotty doesn't wanna have to break down a paragraph. Therapy overview VC T X 210 is a CRISPR edited system stem cell therapy designed to replace insulin producing beta cells and patients with type one. The therapy uses CRISPR cast nine gene editing technology to modify stem cells making them capable of evading the immune system and eliminating the need for immuno suppression. Now we're talking Health Canada let's see the clinical trial application has been approved by Health Canada making it the first gene edited therapy for diabetes to approach clinical trials. Hey, Health Canada. Lovely. The mechanism of therapy V CT X to 10 involves editing donor derived stem cells to create insulin producing beta cells that are implement implanted, excuse me into the patient. These cells are engineered to avoid immune detection and destruction. I would like to maybe do that with some other cells too. About the ones can I could we fix people's thyroid? Could we who wait a minute, there's a lot here isn't there? The phase one trial will evaluate the safety tolerability and immune evasion of VCT x 210 and type one patients oh god bless you. I hope this goes well. therapy is a joint effort between CRISPR therapeutics and vitae site via site. Hey, if anybody wants to come on and talk about this, I'd love to hear more about this from one of these entities and I will reach out and see what I can figure out. Hey, this chat GPT tells us what's going on segment is pretty freakin great. And inhaled insulin study the new data presented at the ADL at fourth Scientific Sessions indicates that inhaled insulin are present safe and effective for improving glycemic control and HPA once the levels and type one patients. I'm actually going to have an episode about this with Dr. Blevins coming up in a couple of weeks. You know Dr. Blevins from the GLP episodes, and he's going to be talking to us about Frezza and something else. I don't want to give it everything away right now but stuff is coming. All right. Well, there's

there's the chat GVT effort. diatribe came back with a little little recap of stuff. They heard about pumps. They talked about tide pool being at Ada with their new twist AI D system, which of course is tide pool loop and this new twist pump. That Dexcom stello will be available in August. This is already something we've talked about on the podcast before Dexcom stello. Of course, the CGM is designed to be worn on the back of the arm. Though people with diabetes tend to get creative with placement says the author for up to 15 days and the readings are displayed directly using a smartphone app spokesperson said pricing will be announced closer to the launch date. This is like no. This is for type twos that don't use insulin. You won't need a prescription for this. This will be a walk in and buy thing. By the way. This article was written by Paul Helsel for diatribe. Paul, thank you very much for letting us read your article. What else does Paul say? There's some study results from tandem Medtronic and insolate. At the ADA conference tandem highlighted at small mobi pumps. Citing a recent study conducted by the Barbara Davis Center for diabetes the University of Colorado, which showed time and range improved without an increase in time below range using control IQ. The device integrates with iPhone Babaji 67, Medtronic offered data showing that its mini med seven ADG AI D system reduces sleep interruptions and improve time and range during sleep cool. The system's ability to deliver small bonuses every five minutes company said also helped reduce the dawn phenomenon rate from 12.2% to 4.5. And slightly increased the time and range from 12 to 6am. It's insolate. Excuse me, insula which is Omni pod presented a study at Ada showing its Omnipod five system could benefit people with type two diabetes who use insulin participating participants excuse me who were previously using injections or pump therapy saw improvement, they wouldn't see reduced blood sugar spikes and hyperglycemia. The company said as well, time and range improved by 20%. And overall insulin was used by overall insulin was reduced by 23 units a day. That's really great. Thank you diatribe. Thank you, Paul. Lovely, lovely. Lovely. Like I said, I'm gonna have Dr. Blevins on to talk about a Frezza. And actually, he's gonna come on and talk about some other stuff too. Maybe we'll I don't want to give it away. Again, I look at me, I'm teasing myself. I shouldn't do that. This ain't bad. This is not bad for a little bit of news this week. Hmm. Looks like there are people out there working with stem cells, people working on automated insulin delivery systems to get them working better and to cover more people. Dexcom is going to be helping out with type two diabetes with their new product. So all in all, a good week at Ada. I got a lot of reports back from Ada, my, my people were everywhere telling me the good and the bad and sometimes the ugly. And I'll tell you what made me think maybe I'll go to ADA set up a little booth and do a little Juicebox Podcast thing at the 85th annual EDA. So Scott he's looking into that there's little news for me to you. I don't need other people running around talking about me. I can talk about myself. What else we got here, kids, anything anything else you want to know? Oh, July 2, the juicebox cruise goes on sale. Head into the private Facebook group or the public Facebook page. We are doing a cruise for Juicebox Podcast listeners. You can get all the details there that goes on sale July 2 in the Facebook group. First we want to make sure that everybody who is a Facebook group member has an opportunity to get a cabin before we go wider with the offering. So go check that out. We want to get a bunch of Juicebox Podcast listeners together family, adults, anybody who's interested in coming, be a great five day trip. We're going to make a couple of ports of call in Mexico all the details of the details will be in the post. And there'll be a private Facebook group for people who put down a deposit so you guys can meet each other and really get to know each other before the cruise embarks on June 14 and 2025 I'll add a little bit of my own news. A group of coders have split a branch of IEPs off to something called trio. It's in beta right now. Arden's running it loving the loving the branch very much. If you're a DIY looper and you've ever thought about looking into IEPs I might look at trio instead. For me to you, I think that's worth looking into. Alright, so I guess that's the end of Scott reads the internet today. I wish you were here to say no Scott s this of the chat GPT overlord. But I don't I don't have anything else. Although you know what, hold on. What's that new Canadian insulin that once weekly, we're going to be just seeing if Chechi here is what I'm talking about. We talked about a genuine Yeah, it's called a weekly. I will say again, Novo Nordisk Whoever named it genius. Aw, IQ li a weekly. Health Canada approved a weekly on March 12 2020. Ford is set to become available across Canada starting June 30th. Geez, that's like right now. 2024. Weekly is a Basal insulin designed to be administered once a week. It works through a time release mechanism gradually releasing insulin over the course of a week. Clinical trials included both type one and type two patients, but the therapy is expected to be most beneficial for those with type two diabetes. type one diabetes patients will still require additional fast acting insulin injections at mealtimes. Well, yeah, but that that might just be Chachi Beatty, not quite understanding. I mean, if it's a once weekly Basal, then that's valuable for everybody. The most common side effects included hypoglycemia, and injection site reactions with bruising, pain and swelling that's from Yahoo Finance. A weekly aims to improve glycemic control with fewer injections, potentially increasing adherence to insulin therapy and reducing the risk of diabetes related complications, etc. and so on. Hey, if somebody in Canada ends up using a weekly I'd love for you to come on and tell me about it. That'd be absolutely wonderful. But I guess that's gonna be it for now. I will. I will see you again soon. Let me know if we should keep doing this little news thing. I'm up for this. I like this a lot. But if you guys hate it, like I'm not gonna You don't I mean, send me an email.

Did you know if just one person in your family has type one diabetes, you're up to 15 times more likely to get it to screen it like you mean it. One blood test can spot type one diabetes early. Tap now, talk to a doctor or visit screened for type one.com For more info. If you're looking for community around type one diabetes, check out the Juicebox Podcast private Facebook group Juicebox Podcast type one diabetes, but everybody is welcome. Type one type two gestational loved ones. It doesn't matter to me. If you're impacted by diabetes, and you're looking for support, comfort or community check out Juicebox Podcast type one diabetes on Facebook. The diabetes variable series from the Juicebox Podcast goes over all the little things that affect your diabetes that you might not think about travel and exercise to hydration and even trampolines. juicebox podcast.com. Go up in the menu and click on diabetes variables. If you're not already subscribed or following in your favorite audio app, please take the time now to do that. It really helps the show and get those automatic downloads set up so you never miss an episode. Thank you so much for listening. I'll be back very soon with another episode of The Juicebox Podcast.